Aye, I actually played the PnP Cyberpunk 2020, I really enjoyed it as it was a nice change from the usual Dragonlance/Forgotten realms campaigns we also were playing at the time, On a few levels I actually enjoyed it more (Being more of a techy minded person) I'm really looking forward to this as I've been waiting for a game of this Genre for a very very long time that might actually be good. I really hope they don't mess it up.
IMO it needs to be a Multiplayer Coop, as playing something based on a PnP system would be dumb as a single player, it also needs to be an evolving (sandbox) style game with map sizes like GTA series.
I pretty much imagine Being able to get in a group of 4 people (who hopefully won't all be solos) and for example try and take down a large corporate bank.
Netrunners would disable the security systems while the Fixers bribe the bank guards to be "absent" for a while, while the solos go in an take the money..
Well that's in my mind anyway. there is so much i'd like to see.