There are a few Episode missions that have Nolan and Irisa in them (about 5 I think) that appear to be before the TV Show, which do seem to tie in ok to the tv show. However the Game is based around San Fran area and the tv show is around St. Louis, so nowhere close
I've read that the first series is already set in stone, so hardly any crossover (which is a bit dumb) however the second series of the TV show, if it makes it along with the game, will tie in considerably more.
I watched the first TV episode and I liked it quite a bit tbh, The game is pretty fun, quite samey however, just think of it as a Rift Shooter and you won't really go wrong, it's still pretty fun blasting stuff and riding vehicles around.