Yeah, I haven't found the need to move my buttons around yet. I just use the vanilla UI with a handful of meter and timer mods.
SW_Stats, green bars on right (damage meter like Recount, which stores the entire combat log, and tallys it all up with a breakdown of damage done, taken, healing, spells cast, etc etc.)
Omen, to the left of SW_Stats (threat meter, takes into acount proximity threat, and copes with target switching fairly well)
Ora2 tank windows next to that, shows Tank, then Target, then Target's Target. Allows you to see who the mobs are attacking, as well as keep tabs on the tanks and the mobs themselves.
You can see VE wearing off on the far left, that's erm... DoTimer I think. Not sure.
The bars on the top and bottom are Titan Bars, which is a framework for a bunch of other mods made specifically to work with it. Bag space, Durability, DPS, TPS, etc can be shown on there. Mine's quite stripped down.
Thought I'd use a shot of me having a dirt-nap, for old time's sake.